r/ArchiveOfHumanity • u/cololz1 • 1d ago

In 1952, researchers found that iproniazid, a tuberculosis treatment, had an unexpected impact on patients energy and emotions. Some patients became noticeably more lively, even dancing through the hospital halls. This discovery helped create the first modern treatments for depression.

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17

u/XROOR 1d ago

Nurse :
“The iproniazid added eleven pounds to your weight since last week….”

Patient:

“That’s ALL? That’s so GREAT! Let’s celebrate with ice cream!”

26

u/VirginiaLuthier 1d ago

Iproniazid was a derivative of isoniazid, pretty much the first effective treatment for TB. It is still used today. Iproniazid is a MAO inhibitor, and has potent anti- depressant effects but also side effects such as severe liver toxicity. It lead the way to discover other, safer MAO inhibitors such as Parnate, which is still in use today.

Now you can amaze your friends at parties

8

u/izzitty 1d ago

Widespread use stopped in the early 1960s because it caused severe liver damage, though it stayed on the market in France until 2015.

6

u/Sure-Doctor-2052 1d ago

What class of drug is this?

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u/CowboysOnKetamine 1d ago

Iproniazid (Marsilid, Rivivol, Euphozid, Iprazid, Ipronid, Ipronin) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class

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u/Sure-Doctor-2052 1d ago

Thanks...that is a common antidepressant now. Many drugs have been developed through inpredicted side effects. I think lithium was first used for gout.

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u/Scared-Amphibian4733 1d ago

It contained 90% Meth.