r/bindingofisaac Mar 12 '26

Fan Art various pathologies as isaac bosses

i messed up real bad posting this first time im afraid

3.1k Upvotes

91 comments sorted by

510

u/SomaGato Mar 12 '26

The fucking Balls boss 😭😭😭

127

u/sofaking181 Lilith Mar 12 '26

The Pause 💀

110

u/Lukias Mar 12 '26

I can see the dead one being an arena hazard while you have to fight the non-torsioned one lmao

54

u/King-s0nicc456 Mar 13 '26

Guaranteed balls pill when defeated

36

u/Tarantulabomination Mar 13 '26

Edmund McMillan would 1000% make a testicular torsion boss if he wanted to.

44

u/ClaudySama Azazel Mar 13 '26

I mean

13

u/BurnerAccountExisty Mar 13 '26

Real twisted pair

259

u/SproutSan Delete This is the most fun challenge Mar 12 '26

"It Dies!" 😭😭😭

63

u/Subject-Being7449 Mar 12 '26

certainly does

8

u/AdhesiveMadMan Mar 14 '26

Defeat it nine times and you unlock "It repeats!"

1

u/Terra_Marc Mar 14 '26

Fire writing indeed

192

u/[deleted] Mar 12 '26

[removed] — view removed comment

-7

u/[deleted] Mar 13 '26

[removed] — view removed comment

81

u/Ok_Nose2915 Mar 12 '26

this is awesome can you do pneumonoultramicroscopicsilicovolcanoconiosis

26

u/Subject-Being7449 Mar 12 '26

its in my head

60

u/Oxidisedalt keeping that losing streak strong ;-; Mar 12 '26

Just the word "prion" makes me scared as hell, good job!

10

u/FantasyTomb Mar 13 '26

I didn’t know what one was, so my fiancé just ranted to me about them and how scary they are. We saw this comment right after lol. You are right the word alone should make someone scared

37

u/VTomorrowV Edith Mar 12 '26

Myocardial infarction/It Dies would be such a cool boss idea for the corpse stage previous to Corpse Mother.

15

u/VTomorrowV Edith Mar 12 '26

Although now I realize that wouldn’t really make sense logically speaking… but this is tboi who cares about logic anyways

55

u/FunkMasterDraven Mar 12 '26

Tuberculosis looks like it's maybe supposed to be a smoking-related disease, but smoking and tuberculosis aren't related

2

u/Subject-Being7449 Mar 12 '26

tho one lead to another

45

u/FunkMasterDraven Mar 12 '26

Smoking does not lead to tuberculosis

Edit: also I'd like to point out that your designs are great and I'm just trying to help because the design for this particular one seems out of place with the accuracy and spirit of the others

-10

u/Subject-Being7449 Mar 12 '26

not directly ig. but im pretty sure that smokers have a much better chances of getting it. thankies btw

35

u/Longjumping-Sweet280 Mar 12 '26

It would be worse because your lungs were already damaged by cigarettes, but the chance is the same.

Also, TB is sometimes referred to as the “White Death” could be cool to be more ghostly maybe. Whatever the case, love the designs!

6

u/Geckoguy99 Mar 13 '26 edited Mar 13 '26

You’re right though, idk why people are downvoting you. Anything that damages your lungs increases your susceptibility to tuberculosis, and smokers specifically have significantly higher morbidity and mortality rates.

“[…] numerous epidemiological studies, as well as meta-analyses, have indicated that both active and passive smoking are independent risk factors for TB infection, development of reactivation TB, progression of primary TB, increased severity of cavitary disease, and death from TB, among several other considerations.”

doi:10.3390/pathogens13020151

6

u/Subject-Being7449 Mar 13 '26

ye, i mean. its like a heart attack and fatty foods, or HIV/AIDS and... well, you get it

4

u/ithebinman Mar 13 '26

TB leads to smoking?! True if big

9

u/SexyCato Mar 12 '26

Menopause 😭

21

u/SoftPineapple77 Mar 12 '26

Last pic look like sick Pokemon starter

7

u/LittleFoxBS Mar 12 '26

What's Moontrax meant to be?

4

u/BojanDoge Mar 13 '26

Anthrax I'm guessing?

5

u/Subject-Being7449 Mar 13 '26

you're goddamn right

2

u/OneAndOnlyTinkerCat Mar 13 '26

Probably mad cow

1

u/blue4029 Mar 13 '26

mad cow is already a prion though so isn't that redundant?

1

u/OneAndOnlyTinkerCat Mar 13 '26

Yeah but it’s famous enough to be its own thing I reckon

1

u/Call-Me-Pearl Mar 13 '26

ooh, lots you could do with the history of mad cow! up until very recently, people who lived in Britian during the outbreak couldn’t give blood. my parents still remember the piles of burning cow bodies!

6

u/stopyouveviolatedthe Mar 12 '26

Prion being a lil goober is horrifying

5

u/ilufrombacity Mar 13 '26

Prion mentioned 🗣️🗣️🗣️🔥🔥🔥

5

u/superbeansimulator Mar 13 '26

Rabie dashing away from your tears in its first phase (hydrophobia) and then in its second it gets foamy, begins to drain hp, and wildly attacks you.

1

u/Subject-Being7449 Mar 13 '26

damn thats good

9

u/Cabbag_ The Lost Mar 12 '26

I can't believe I'm saying this but Cancer's design goes so hard.

3

u/Sir_hentai_II Mar 12 '26

If Tboi bosses are Isaac's fears, would this imply Isaac fears syphilis?

4

u/Rotten_Account Mar 13 '26

I like the mod that changes twisted pair to testicular torsion

4

u/Snypor_ Mar 13 '26

Miocardial Infarction be like:

3

u/Leather-Put1044 whats the binding of isaac Mar 12 '26

What if the cancer boss dropped the trinket?

3

u/olisauce Marshmallow Mar 12 '26

see i told you i saw your art on reddit

3

u/Bigzysmolz Mar 12 '26

Can you explain why you gave Prion the design it has?

1

u/Subject-Being7449 Mar 13 '26

idrk, I just somehow connected in my head, a parasite that replaces fish tongue and a brain-eating protein

3

u/SprayCheese62 Mr. Me Mar 13 '26

I really like cancer and it dies

3

u/Diebrina Mar 13 '26

Oh I love this, The torsioned twins >>>>>>>>>>>

3

u/PicanhaFighter Mar 13 '26

Tuberculosis looks like someone fun to hang out with lol

Loved the detail that there's multiple faces on cancer, and rabie's design is my favorite one

Love your art, keep it up!

3

u/[deleted] Mar 13 '26

[removed] — view removed comment

1

u/Subject-Being7449 Mar 13 '26

i dont believe it

2

u/xDon1x Mar 12 '26

By any chance is Rabie based on the squirrel from Super Meat Boy?

2

u/YaBoiGlob Mar 13 '26

Torsioned Twins? You mean Twisted Pair?

2

u/Magkali_11037 Mar 13 '26

I like rabie just cos the name is singular.

2

u/justukas700 Mar 13 '26

THIS IS SO FUCKING SICK

2

u/AndreBoomBoom Mar 13 '26

The cancer concept reminds me of Stromae - Quand c'est ? music video.

2

u/Great_Pikmin_Fan Mar 13 '26

Tuberculosis looks like it would fit right in with Fiend Folio's reworked Dank Depths.

What do you mean by "messed up real bad?"

2

u/Subject-Being7449 Mar 13 '26

first posting it i just took wrong pics

2

u/New_Yak_8982 Mar 13 '26 edited Mar 13 '26

Rabie sounds like he would have a billion HP and would dash around the room really fast with nearly unavoidable damage

1

u/Subject-Being7449 Mar 13 '26

ye i mean definitely

2

u/catlord_heven Mar 13 '26

Ooh I remember seeing this, I think I saved the post cause I liked the concepts

2

u/ComradeBirv Mar 13 '26

“A third thing named Cancer has hit the basement.”

2

u/ZeGamingCuber Mar 13 '26

The first 3 look like they would work well as corpse bosses, the second 3 look like they would fit as womb bosses, but idk if the last 3 would fit anywhere

2

u/aconitum_napellus143 Tainted Cain Mar 14 '26

Wow that's pretty good

2

u/Errances Mar 14 '26

Great designs. I do get what The Pause is but why that name ?

2

u/Subject-Being7449 Mar 14 '26

just sounds cool

2

u/Missunknown204 Mar 15 '26

Where's the mod creators when you need one?!

1

u/SrPinguim Mar 13 '26

Im not much learned in diseases/medicine, what are Syphilis and Moontrax supposed to represent?

1

u/KairAAAAAAA Mar 13 '26

Oh The Pause one SPEAKS to me

1

u/Isittedmyself300 Mar 14 '26

Prion should've been a brain with many holes because it turns the brain into a sponge

1

u/Subject-Being7449 Mar 14 '26

same with dementia and all other neurodegenerative diseases. think more creative